This study evaluated a new formulation of titanium tetrafluoride (TiF4) combined with PEG-citrate dendrimer to improve its stability and anti-caries effect. Thirty-six human teeth were treated with TiF4, dendrimer alone, or the TiF4-dendrimer gel and subjected to pH cycling. Microhardness, Raman spectroscopy, and EDS analyses showed that the new TiF4-dendrimer formulation reduced microhardness loss more effectively than TiF4 alone, promoted deeper and more uniform penetration of titanium and fluoride, and preserved higher subsurface calcium content.

Conclusion: The newly developed TiF4-dendrimer formulation enhances TiF4 efficacy and represents a promising strategy to prevent dentin demineralization and caries. This new formulation may serve as an effective approach to prevent or limit dental caries.

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نویسنده:

Taraneh Estedlal 1, Ladan Ranjbar Omrani 2, Khosrou Abdi 3, Niyousha Rafeie 4, Zohreh Moradi 5